Lysostaphin in treatment of neonatal Staphylococcus aureus infection.
نویسندگان
چکیده
This study describes lysostaphin's effect against methicillin-sensitive Staphylococcus aureus in suckling rats. Standard techniques determined minimal inhibitory and bactericidal concentrations, pharmacokinetics, and efficacy. The numbers of surviving rats after vancomycin, oxacillin, and lysostaphin treatment were comparable and were different from that of controls (P < 0.00001). Lysostaphin appears effective in the treatment of neonatal S. aureus infection.
منابع مشابه
Lysostaphin as a treatment for systemic Staphylococcus aureus infection in a mouse model.
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 51 6 شماره
صفحات -
تاریخ انتشار 2007